Search results for "Aurora kinase inhibitor MK-0457"

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The role of Aurora-A inhibitors in cancer therapy

2007

Recently, new chemotherapy agents which target the non-structural components of mitosis have been developed. An important protein involved in several mitotic phases is the Aurora-A protein. By means of the phosphorylation of different substrates, Aurora-A regulates the correct development of the various phases of mitosis. The kinase activity of this protein makes Aurora-A an excellent candidate as an oncogene. The first data of Aurora-A involvement in cancer regarded the identification of Aurora-A overexpression in primary breast and colon tumour samples. With regard to the predictive role of Aurora-A, it has been shown that its overexpression disrupts the spindle checkpoint activated by pa…

Aurora inhibitorAntineoplastic Agentsmacromolecular substancesProtein Serine-Threonine KinasesBiologychemistry.chemical_compoundAurora kinaseAurora KinasesNeoplasmsAnimalsHumansKinase activityProtein Kinase InhibitorsMitosisHematologyCell biologyZM447439Aurora-A cancer treatment kinase inhibitor mitosis small moleculeenzymes and coenzymes (carbohydrates)Spindle checkpointNocodazoleOncologyAurora kinase inhibitor MK-0457chemistryembryonic structuresbiological phenomena cell phenomena and immunity

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